The emerging field of omics - large-scale data-rich biological measurements of the genome - provides new opportunities to advance and strengthen research into endocrine-disrupting chemicals (EDCs). Although some EDCs have been associated with adverse health effects in humans, our understanding of their impact remains incomplete. Progress in the field has been primarily limited by our inability to adequately estimate and characterize exposure and identify sensitive and measurable outcomes during windows of vulnerability. Evolving omics technologies in genomics, epigenomics and mitochondriomics have the potential to generate data that enhance exposure assessment to include the exposome - the totality of the lifetime exposure burden - and provide biology-based estimates of individual risks. Applying omics technologies to expand our knowledge of individual risk and susceptibility will augment biological data in the prediction of variability and response to disease, thereby further advancing EDC research. Together, refined exposure characterization and enhanced disease-risk prediction will help to bridge crucial gaps in EDC research and create opportunities to move the field towards a new vision - precision public health.

中文翻译：

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“组学”和破坏内分泌的化学物质-前进的新途径。

组学的新兴领域-基因组的大规模数据丰富的生物学测量-提供了新的机会来推进和加强对破坏内分泌的化学物质（EDC）的研究。尽管某些EDC与人类健康不良影响相关，但我们对其影响的理解仍然不完整。该领域的进展主要受到我们无法在漏洞窗口期间充分评估和表征暴露以及确定敏感和可衡量的结果的限制。基因组学，表观基因组学和线粒体学中不断发展的组学技术有可能生成增强暴露评估的数据，包括暴露量-终生暴露负担的总和-并提供基于生物学的个体风险估计。应用组学技术来扩展我们对个体风险和易感性的了解，将在预测变异性和对疾病的反应中增加生物学数据，从而进一步推进EDC研究。完善的接触特性描述和增强的疾病风险预测将共同帮助弥合EDC研究中的关键差距，并创造机会将这一领域推向新的视野-精准的公共卫生。