Interferon effector functions and autophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict replication of intracellular pathogens. In this issue of Cell Host and Microbe, Biering et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-inducible GTPases to inhibit replication of positive-sense RNA viruses.

中文翻译：

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抗病毒战争：LC3招募GTPases

干扰素效应子功能和自噬是细胞自主免疫的进化保守分支，可限制细胞内病原体的复制。在本期《细胞宿主与微生物》（Cell Host and Microbe）中，Biering等人（2017）展示了宿主细胞如何共同选择自噬蛋白和IFN诱导型GTPases的顺序作用来抑制正向RNA病毒的复制。