Invadopodia are a subset of invadosomes that are implicated in the integration of signals from the tumor microenvironment to support tumor cell invasion and dissemination. Recent progress has begun to define how tumor cells regulate the plasticity necessary for invadopodia to assemble and function efficiently in the different microenvironments encountered during dissemination in vivo. Exquisite mapping by many laboratories of the pathways involved in integrating diverse invadopodium initiation signals, from growth factors, to extracellular matrix (ECM) and cell–cell contact in the tumor microenvironment, has led to insight into the molecular basis of this plasticity. Here, we integrate this new information to discuss how the invadopodium is an important conductor that orchestrates tumor cell dissemination during metastasis.

Invadopodia是invadosome的子集，与来自肿瘤微环境的信号整合有关，以支持肿瘤细胞的侵袭和扩散。最近的进展已开始定义肿瘤细胞如何调节昆虫足的必要可塑性，以在体内传播过程中遇到的不同微环境中有效组装和发挥功能。。许多实验室对肿瘤微环境中涉及从生长因子到细胞外基质（ECM）以及细胞间接触的各种invadopodium起始信号进行整合的途径的精确定位，已经使人们洞悉了这种可塑性的分子基础。在这里，我们整合了这些新信息，以讨论invadopodium是如何在转移过程中协调肿瘤细胞扩散的重要导体。