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Neural Glycosylphosphatidylinositol-Anchored Proteins in Synaptic Specification
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2017-07-22 , DOI: 10.1016/j.tcb.2017.06.007
Ji Won Um , Jaewon Ko

Glycosylphosphatidylinositol (GPI)-anchored proteins are a specialized class of lipid-associated neuronal membrane proteins that perform diverse functions in the dynamic control of axon guidance, synaptic adhesion, cytoskeletal remodeling, and localized signal transduction, particularly at lipid raft domains. Recent studies have demonstrated that a subset of GPI-anchored proteins act as critical regulators of synapse development by modulating specific synaptic adhesion pathways via direct interactions with key synapse-organizing proteins. Additional studies have revealed that alteration of these regulatory mechanisms may underlie various brain disorders. In this review, we highlight the emerging role of GPI-anchored proteins as key synapse organizers that aid in shaping the properties of various types of synapses and circuits in mammals.



中文翻译:

神经糖基磷脂酰肌醇固定的突触规范中的蛋白质

糖基磷脂酰肌醇(GPI)锚定的蛋白是一类特殊的脂质相关神经元膜蛋白,在轴突引导,突触粘附,细胞骨架重塑和局部信号转导的动态控制中发挥多种功能,尤其是在脂质筏域。最近的研究表明,GPI锚定蛋白的一个子集通过与关键的突触组织蛋白直接相互作用来调节特定的突触粘附途径,从而充当突触发育的关键调节剂。进一步的研究表明,这些调节机制的改变可能是各种脑部疾病的基础。在这篇综述中,我们重点介绍了GPI锚定蛋白作为关键突触组织者的新兴作用,这些蛋白有助于塑造哺乳动物中各种类型的突触和回路的特性。

更新日期:2017-07-22
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