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Mitochondrial Function and Cell Size: An Allometric Relationship
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2017-03-08 , DOI: 10.1016/j.tcb.2017.02.006
Teemu P. Miettinen , Mikael Björklund

Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.



中文翻译:

线粒体功能和细胞大小:异速关系

异速代谢比例的缩放会导致线粒体总氧消耗降低,同时增加生物体的大小。这被认为是生物学的普遍定律。在这里,我们讨论异速生长法如何在细胞水平上对线粒体活性施加大小依赖性的限制。这种依赖细胞大小的线粒体代谢活性导致增殖细胞的代谢非线性缩放,这可以解释大小的稳态。线粒体活性的异速生长可通过线粒体融合和裂变机制来控制,这表明线粒体的连通性可绕过运输限制,而后者是异速生长的推测生物物理基础。由于物理尺寸会影响细胞功能,因此依赖细胞尺寸的代谢与发育,代谢性疾病和衰老直接相关。

更新日期:2017-03-08
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