The reactivation of a stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to restabilize (reconsolidate) the memory can either be reduced by an amnesic agent or enhanced by memory enhancers. The change in memory expression is related to changes in the brain correlates of long-term memory. Many have suggested that such retrieval-induced plasticity is ideally placed to enable memories to be updated with new information. This hypothesis has been tested experimentally, with a translational perspective, by attempts to update maladaptive memories to reduce their problematic impact. We review here progress on reconsolidation updating studies, highlighting their translational exploitation and addressing recent challenges to the reconsolidation field.

中文翻译：

---

内存重组更新的更新

大脑中存储的记忆的重新激活可以使记忆暂时不稳定。在记忆重新稳定（重新巩固）所需的时间期间，记忆可以通过健忘剂减少或通过记忆增强剂增强。记忆表达的变化与长期记忆相关的大脑变化有关。许多人认为，这种检索诱导的可塑性非常适合使记忆能够用新信息进行更新。通过尝试更新适应不良的记忆以减少其有问题的影响，这一假设已经通过实验以转化的角度进行了测试。我们在这里回顾了再整合更新研究的进展，强调了它们的转化开发并解决了再整合领域最近面临的挑战。