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Regulation of Stem Cell Aging by Metabolism and Epigenetics
Cell Metabolism ( IF 29.0 ) Pub Date : 2017-08-17 00:00:00 , DOI: 10.1016/j.cmet.2017.07.019
Ruotong Ren,Alejandro Ocampo,Guang-Hui Liu,Juan Carlos Izpisua Belmonte

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-associated declines in stem cell function are characterized by metabolic and epigenetic changes. Understanding the mechanisms underlying these changes will likely reveal novel therapeutic targets for ameliorating age-associated phenotypes and for prolonging human healthspan. Recent studies have shown that metabolism plays an important role in regulating epigenetic modifications and that this regulation dramatically affects the aging process. This review focuses on current knowledge regarding the mechanisms of stem cell aging, and the links between cellular metabolism and epigenetic regulation. In addition, we discuss how these interactions sense and respond to environmental stress in order to maintain stem cell homeostasis, and how environmental stimuli regulate stem cell function. Additionally, we highlight recent advances in the development of therapeutic strategies to rejuvenate dysfunctional aged stem cells.

中文翻译:

代谢和表观遗传学对干细胞衰老的调节

干细胞衰老和精疲力尽被认为是机体衰老的重要驱动力。与年龄相关的干细胞功能下降的特征是代谢和表观遗传学变化。了解这些变化的潜在机制可能会揭示出改善年龄相关表型和延长人类健康的新型治疗靶标。最近的研究表明,新陈代谢在调节表观遗传修饰中起着重要作用,并且这种调节显着影响衰老过程。这篇综述着重于有关干细胞衰老机制以及细胞代谢与表观遗传调控之间联系的最新知识。此外,我们讨论了这些相互作用如何感测和响应环境压力,以维持干细胞的动态平衡,以及环境刺激如何调节干细胞功能。此外,我们重点介绍了功能失调的衰老干细胞恢复活力的治疗策略的最新进展。
更新日期:2017-08-24
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