当前位置: X-MOL 学术Annu. Rev. Condens. Matter Phys. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Intracellular Oscillations and Waves
Annual Review of Condensed Matter Physics ( IF 22.6 ) Pub Date : 2017-03-31 00:00:00 , DOI: 10.1146/annurev-conmatphys-031016-025210
Carsten Beta 1 , Karsten Kruse 2
Affiliation  

Dynamic processes in living cells are highly organized in space and time. Unraveling the underlying molecular mechanisms of spatiotemporal pattern formation remains one of the outstanding challenges at the interface between physics and biology. A fundamental recurrent pattern found in many different cell types is that of self-sustained oscillations. They are involved in a wide range of cellular functions, including second messenger signaling, gene expression, and cytoskeletal dynamics. Here, we review recent developments in the field of cellular oscillations and focus on cases where concepts from physics have been instrumental for understanding the underlying mechanisms. We consider biochemical and genetic oscillators as well as oscillations that arise from chemo-mechanical coupling. Finally, we highlight recent studies of intracellular waves that have increasingly moved into the focus of this research field.

中文翻译:


细胞内的振荡和波动

活细胞中的动态过程在空间和时间上高度组织。揭示时空模式形成的潜在分子机制仍然是物理与生物学之间的主要挑战之一。在许多不同类型的电池中发现的基本循环模式是自持振荡。它们涉及广泛的细胞功能,包括第二信使信号传导,基因表达和细胞骨架动力学。在这里,我们回顾了细胞振荡领域的最新进展,并重点研究了来自物理学的概念有助于理解潜在机理的情况。我们考虑生物化学和遗传振荡器以及化学机械耦合引起的振荡。最后,

更新日期:2017-03-31
down
wechat
bug