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Flavonoid and Galloyl Glycosides Isolated from Saxifraga spinulosa and Their Antioxidative and Inhibitory Activities against Species That Cause Piroplasmosis
Journal of Natural Products ( IF 5.1 ) Pub Date : 2017-08-23 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00142
Duger Badral 1, 2 , Batsukh Odonbayar 3 , Toshihiro Murata 3 , Tserendorj Munkhjargal , Bumduuren Tuvshintulga , Ikuo Igarashi , Keisuke Suganuma , Noboru Inoue 4 , Adelheid H. Brantner 5 , Gendaram Odontuya 6 , Kenroh Sasaki 3 , Javzan Batkhuu 1
Affiliation  

Eight new flavonoid-based 3′-O-β-d-glucopyranosides (18) and three new galloyl glucosides (9, 11, 12), were isolated from the aerial parts of Saxifraga spinulosa, along with 25 known compounds. The structures of the new compounds were elucidated by spectroscopic methods. Most of the isolated compounds exhibited potent DPPH radical-scavenging activities. Further, their inhibitory activities were evaluated against Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, protozoan parasites that cause piroplasmosis in livestock. The results indicated that several of these compounds showed growth-inhibitory effects on such organisms that cause piroplasmosis.

中文翻译:

类黄酮和没食子苷隔离虎耳草椤及其抗氧化和抗物种的抑制活性,导致焦虫病

八个新黄酮类3'- ö -β- d -glucopyranosides(1 - 8)和三个新的没食子酰基糖苷(91112),从地上部分分离虎耳草椤,连同25种已知的化合物。通过光谱方法阐明了新化合物的结构。多数分离出的化合物均具有有效的清除DPPH自由基的活性。此外,评估了它们对牛肝杆菌,大巴贝,大巴贝虫和卡氏泰勒的抑制活性。,会导致牲畜胞浆虫病的原生动物寄生虫。结果表明,这些化合物中的几种对引起萤火虫病的生物显示出生长抑制作用。
更新日期:2017-08-23
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