The neocortex comprises multiple information processing streams mediated by subsets of glutamatergic pyramidal cells (PCs) that receive diverse inputs and project to distinct targets. How GABAergic interneurons regulate the segregation and communication among intermingled PC subsets that contribute to separate brain networks remains unclear. Here we demonstrate that a subset of GABAergic chandelier cells (ChCs) in the prelimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to the basolateral amygdala (_BLAPC) compared to those projecting to contralateral cortex (_CCPC). These ChCs in turn receive preferential input from local and contralateral _CCPCs as opposed to _BLAPCs and BLA neurons (the prelimbic cortex-BLA network). Accordingly, optogenetic activation of ChCs rapidly suppresses _BLAPCs and BLA activity in freely behaving mice. Thus, the exquisite connectivity of ChCs not only mediates directional inhibition between local PC ensembles but may also shape communication hierarchies between global networks.

中文翻译：

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枝形吊灯细胞对锥体神经元集合和皮层子网络的选择性抑制控制。

新皮质包括由谷氨酸能锥体细胞（PC）的子集介导的多个信息处理流，该子集接收各种输入并投射到不同的靶标。尚不清楚GABA能神经元如何调控混杂的PC亚群之间的隔离和交流，而这些PC亚群有助于形成独立的大脑网络。在这里，我们证明了在前肢皮层中支配PC的前肢皮层中的GABA能枝形吊灯细胞（ChCs）与投影到对侧皮层（_CC PC）的PC相比，选择性地控制了投射到基底外侧杏仁核（_BLA PC）的PC。这些ChC依次从本地和对等_CC PC接收优惠输入，而不是_BLAPC和BLA神经元（前肢皮质BLA网络）。因此，ChCs的光遗传学激活迅速抑制行为自由的小鼠中的_BLA PC和BLA活性。因此，ChC的精妙连通性不仅可以调解本地PC集成之间的定向抑制，还可以塑造全球网络之间的通信层次结构。