Bone is the most common organ affected by metastatic breast cancer. Targeting cancers within the bone remains a great challenge due to the inefficient delivery of therapeutic to bone. In this study, a polyethylene glycol (PEG) coated nanoparticles (NPs) made of a Zn^2 + coordination polymer was linked with a bone seeking moiety, alendronate (ALN), to deliver cisplatin prodrug (DSP) to the bone. The particle sizes of this novel system, [email protected] NPs, were regulated by adjusting the volume ratio of water phase to oil phase in microemulsion. It was small enough (about 55 nm) to extravasate through the clefts (80 nm) of the bone's sinusoidal capillaries and localize into metastatic bones. [email protected] NPs showed much higher affinity for hydroxyapatite in vitro and bone in vivo than non-targeted [email protected] NPs and cisplatin. In addition, the in vivo biodistribution studies demonstrated that about 4-fold of platinum was delivered to the bone metastatic lesions than that in healthy bones by [email protected] NPs intravenously. Finally, [email protected] NPs not only inhibited the tumor growth efficiently but also reduced the osteocalastic bone destruction. Besides, [email protected] NPs showed significantly reduced toxicity of cisplatin. These results indicate that the [email protected] NPs have a great potential in enhancing chemotherapeutic efficacy for the treatment of bone metastatic breast cancer.

骨是受转移性乳腺癌影响的最常见器官。由于不能有效地将治疗剂输送至骨骼，因此靶向骨骼内的癌症仍然是一个巨大的挑战。在这项研究中，将由Zn ^{2 +}配位聚合物制成的聚乙二醇（PEG）包覆的纳米颗粒（NPs）与寻骨部分阿仑膦酸盐（ALN）连接，以将顺铂前药（DSP）递送至骨骼。通过调节微乳液中水相与油相的体积比，可以调节这种新型系统（受电子邮件保护的NP）的粒径。它足够小（约55 nm），可以穿过骨骼的正弦毛细管的缝隙（80 nm）渗出并定位在转移性骨骼中。[电子邮件保护] NPs对羟基磷灰石的体外和骨骼显示出更高的亲和力体内比非靶向[受电子邮件保护的] NP和顺铂要高。此外，体内生物分布研究表明，通过[电子邮件保护] NP静脉注射到骨转移病变中的铂比健康骨骼中的铂高约4倍。最后，[电子邮件保护的] NPs不仅有效地抑制了肿瘤的生长，而且减少了破骨性骨的破坏。此外，[受电子邮件保护的] NPs显着降低了顺铂的毒性。这些结果表明，[电子邮件保护的] NP具有增强治疗骨转移性乳腺癌的化学治疗功效的巨大潜力。