Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A,Organic Chemistry Frontiers

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Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-08-15 00:00:00 , DOI: 10.1039/c7qo00550d
Hao Zhang _{1,

2,

3,

4,

5} , Shiqiang Ma _{1,

2,

3,

4,

5} , Zhimin Xing _{1,

2,

3,

4,

5} , Lin Liu _{1,

2,

3,

4,

5} , Bowen Fang _{5,

6,

7,

8} , Xingang Xie _{1,

2,

3,

4,

5} , Xuegong She _{1,

2,

3,

4,

5}

Affiliation

A tandem radical cyclization reaction towards the 6/6/5 fused tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields. In this transformation, two C–C bonds and two rings were formed successively via a tandem 5-exo-trig/6-endo-trig cyclization reaction. 5-epi-7-deoxy-Isoabietenin A was also synthesized efficiently via this strategy.

中文翻译：

通过串联自由基环化反应快速构建6/6/5三环骨架，并将其应用于5- epi -7-deoxy-isoabietenin A的合成

大量存在于天然产物中的向6/6/5稠合三环骨架的串联自由基环化反应已适度提高到了良好的收率。在这种转化中，通过串联的5- exo- trig / 6- endo- trig环化反应连续形成两个CC键和两个环。通过这种策略也有效地合成了5- epi -7-脱氧-异豆蛋白A。

更新日期：2017-08-23

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