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Facile Synthesis of Uniform Virus-like Mesoporous Silica Nanoparticles for Enhanced Cellular Internalization
ACS Central Science ( IF 18.2 ) Pub Date : 2017-07-26 00:00:00 , DOI: 10.1021/acscentsci.7b00257
Wenxing Wang 1 , Peiyuan Wang 1 , Xueting Tang 1 , Ahmed A. Elzatahry 2 , Shuwen Wang 1 , Daifallah Al-Dahyan 3 , Mengyao Zhao 1 , Chi Yao 1 , Chin-Te Hung 1 , Xiaohang Zhu 1 , Tiancong Zhao 1 , Xiaomin Li 1 , Fan Zhang 1 , Dongyuan Zhao 1
Affiliation  

The low-efficiency cellular uptake property of current nanoparticles greatly restricts their application in the biomedical field. Herein, we demonstrate that novel virus-like mesoporous silica nanoparticles can easily be synthesized, showing greatly superior cellular uptake property. The unique virus-like mesoporous silica nanoparticles with a spiky tubular rough surface have been successfully synthesized via a novel single-micelle epitaxial growth approach in a low-concentration-surfactant oil/water biphase system. The virus-like nanoparticles’ rough surface morphology results mainly from the mesoporous silica nanotubes spontaneously grown via an epitaxial growth process. The obtained nanoparticles show uniform particle size and excellent monodispersity. The structural parameters of the nanoparticles can be well tuned with controllable core diameter (∼60–160 nm), tubular length (∼6–70 nm), and outer diameter (∼6–10 nm). Thanks to the biomimetic morphology, the virus-like nanoparticles show greatly superior cellular uptake property (invading living cells in large quantities within few minutes, <5 min), unique internalization pathways, and extended blood circulation duration (t1/2 = 2.16 h), which is much longer than that of conventional mesoporous silica nanoparticles (0.45 h). Furthermore, our epitaxial growth strategy can be applied to fabricate various virus-like mesoporous core–shell structures, paving the way toward designed synthesis of virus-like nanocomposites for biomedicine applications.

中文翻译:

轻松合成均匀的病毒样介孔二氧化硅纳米粒子,增强细胞内在化

当前纳米粒子的低效率细胞摄取特性极大地限制了它们在生物医学领域中的应用。在这里,我们证明了新型病毒样介孔二氧化硅纳米粒子可以很容易地合成,显示出极大的细胞摄取特性。通过新颖的单胶束外延生长方法,在低浓度表面活性剂油/水双相系统中成功合成了具有尖锐管状粗糙表面的独特病毒样介孔二氧化硅纳米粒子。病毒样纳米颗粒的粗糙表面形态主要是通过外延生长过程自发生长的中孔二氧化硅纳米管引起的。所获得的纳米颗粒显示出均匀的粒径和优异的单分散性。纳米粒子的结构参数可以通过可控的核心直径(〜60–160 nm),管状长度(〜6–70 nm)和外径(〜6–10 nm)很好地调整。由于具有仿生形态,这种病毒样纳米颗粒显示出非常优越的细胞摄取特性(在不到5分钟的几分钟内大量侵入活细胞),独特的内化途径和延长的血液循环持续时间(t 1/2 = 2.16 h),比传统的中孔二氧化硅纳米粒子(0.45 h)长得多。此外,我们的外延生长策略可用于制造各种类似病毒的介孔核-壳结构,为设计用于生物医学用途的类似病毒的纳米复合材料的合成铺平了道路。
更新日期:2017-08-23
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