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Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial.
The Lancet ( IF 168.9 ) Pub Date : 2017-10-01 , DOI: 10.1016/s1470-2045(17)30517-x Michael Weller , Nicholas Butowski , David D Tran , Lawrence D Recht , Michael Lim , Hal Hirte , Lynn Ashby , Laszlo Mechtler , Samuel A Goldlust , Fabio Iwamoto , Jan Drappatz , Donald M O'Rourke , Mark Wong , Mark G Hamilton , Gaetano Finocchiaro , James Perry , Wolfgang Wick , Jennifer Green , Yi He , Christopher D Turner , Michael J Yellin , Tibor Keler , Thomas A Davis , Roger Stupp , John H Sampson , Nicholas Butowski , Jian Campian , Lawrence Recht , Michael Lim , Lynn Ashby , Jan Drappatz , Hal Hirte , Fabio Iwamoto , Laszlo Mechtler , Samuel Goldlust , Kevin Becker , Gene Barnett , Garth Nicholas , Annick Desjardins , Tara Benkers , Naveed Wagle , Morris Groves , Santosh Kesari , Zsolt Horvath , Ryan Merrell , Richard Curry , James O'Rourke , David Schuster , Mark Wong , Maciej Mrugala , Randy Jensen , John Trusheim , Glenn Lesser , Karl Belanger , Andrew Sloan , Benjamin Purow , Karen Fink , Jeffrey Raizer , Michael Schulder , Suresh Nair , Scott Peak , James Perry , Alba Brandes , Michael Weller , Nimish Mohile , Joseph Landolfi , Jon Olson , Gaetano Finocchiaro , Ross Jennens , Paul DeSouza , Bridget Robinson , Marka Crittenden , Kent Shih , Alexandra Flowers , Shirley Ong , Jennifer Connelly , Costas Hadjipanayis , Pierre Giglio , Frank Mott , David Mathieu , Nathalie Lessard , Sanchez Juan Sepulveda , József Lövey , Helen Wheeler , Po-Ling Inglis , Claire Hardie , Daniela Bota , Maciej Lesniak , Jana Portnow , Bruce Frankel , Larry Junck , Reid Thompson , Lawrence Berk , John McGhie , David Macdonald , Frank Saran , Riccardo Soffietti , Deborah Blumenthal , Sá Barreto Costa Marcos André de , Anna Nowak , Nimit Singhal , Andreas Hottinger , Andrea Schmid , Gordan Srkalovic , David Baskin , Camilo Fadul , Louis Nabors , Renato LaRocca , John Villano , Nina Paleologos , Petr Kavan , Marshall Pitz , Brian Thiessen , Ahmed Idbaih , Jean Sébastien Frenel , Julien Domont , Oliver Grauer , Peter Hau , Christine Marosi , Jan Sroubek , Elizabeth Hovey , P.S. Sridhar , Lawrence Cher , Erin Dunbar , Thomas Coyle , Jane Raymond , Kevin Barton , Michael Guarino , Sumul Raval , Baldassarre Stea , Jorge Dietrich , Kirsten Hopkins , Sara Erridge , Joachim-Peter Steinbach , Losada Estela Pineda , Quintero Carmen Balana , Barco Berron Sonia del , Miklós Wenczl , Katalin Molnár , Katalin Hideghéty , Alexander Lossos , Linde Myra van , Ana Levy , Rosemary Harrup , William Patterson , Zarnie Lwin , Sith Sathornsumetee , E-Jian Lee , Jih-Tsun Ho , Steven Emmons , J. Paul Duic , Spencer Shao , Hani Ashamalla , Michael Weaver , Jose Lutzky , Nicholas Avgeropoulos , Wahid Hanna , Mukund Nadipuram , Gary Cecchi , Robert O'Donnell , Susan Pannullo , Jennifer Carney , Mark Hamilton , Mary MacNeil , Ronald Beaney , Michel Fabbro , Oliver Schnell , Rainer Fietkau , Guenther Stockhammer , Bela Malinova , Karel Odrazka , Martin Sames , Gil Miguel Gil , Evangelia Razis , Konstantin Lavrenkov , Guillermo Castro , Francisco Ramirez , Clarissa Baldotto , Fabiana Viola , Suzana Malheiros , Jason Lickliter , Stanislaw Gauden , Arunee Dechaphunkul , Iyavut Thaipisuttikul , Ziad Thotathil , Hsin-I Ma , Wen-Yu Cheng , Chin-Hong Chang , Fernando Salas , Pierre-Yves Dietrich , Christoph Mamot , Lakshmi Nayak , Shona Nag
The Lancet ( IF 168.9 ) Pub Date : 2017-10-01 , DOI: 10.1016/s1470-2045(17)30517-x Michael Weller , Nicholas Butowski , David D Tran , Lawrence D Recht , Michael Lim , Hal Hirte , Lynn Ashby , Laszlo Mechtler , Samuel A Goldlust , Fabio Iwamoto , Jan Drappatz , Donald M O'Rourke , Mark Wong , Mark G Hamilton , Gaetano Finocchiaro , James Perry , Wolfgang Wick , Jennifer Green , Yi He , Christopher D Turner , Michael J Yellin , Tibor Keler , Thomas A Davis , Roger Stupp , John H Sampson , Nicholas Butowski , Jian Campian , Lawrence Recht , Michael Lim , Lynn Ashby , Jan Drappatz , Hal Hirte , Fabio Iwamoto , Laszlo Mechtler , Samuel Goldlust , Kevin Becker , Gene Barnett , Garth Nicholas , Annick Desjardins , Tara Benkers , Naveed Wagle , Morris Groves , Santosh Kesari , Zsolt Horvath , Ryan Merrell , Richard Curry , James O'Rourke , David Schuster , Mark Wong , Maciej Mrugala , Randy Jensen , John Trusheim , Glenn Lesser , Karl Belanger , Andrew Sloan , Benjamin Purow , Karen Fink , Jeffrey Raizer , Michael Schulder , Suresh Nair , Scott Peak , James Perry , Alba Brandes , Michael Weller , Nimish Mohile , Joseph Landolfi , Jon Olson , Gaetano Finocchiaro , Ross Jennens , Paul DeSouza , Bridget Robinson , Marka Crittenden , Kent Shih , Alexandra Flowers , Shirley Ong , Jennifer Connelly , Costas Hadjipanayis , Pierre Giglio , Frank Mott , David Mathieu , Nathalie Lessard , Sanchez Juan Sepulveda , József Lövey , Helen Wheeler , Po-Ling Inglis , Claire Hardie , Daniela Bota , Maciej Lesniak , Jana Portnow , Bruce Frankel , Larry Junck , Reid Thompson , Lawrence Berk , John McGhie , David Macdonald , Frank Saran , Riccardo Soffietti , Deborah Blumenthal , Sá Barreto Costa Marcos André de , Anna Nowak , Nimit Singhal , Andreas Hottinger , Andrea Schmid , Gordan Srkalovic , David Baskin , Camilo Fadul , Louis Nabors , Renato LaRocca , John Villano , Nina Paleologos , Petr Kavan , Marshall Pitz , Brian Thiessen , Ahmed Idbaih , Jean Sébastien Frenel , Julien Domont , Oliver Grauer , Peter Hau , Christine Marosi , Jan Sroubek , Elizabeth Hovey , P.S. Sridhar , Lawrence Cher , Erin Dunbar , Thomas Coyle , Jane Raymond , Kevin Barton , Michael Guarino , Sumul Raval , Baldassarre Stea , Jorge Dietrich , Kirsten Hopkins , Sara Erridge , Joachim-Peter Steinbach , Losada Estela Pineda , Quintero Carmen Balana , Barco Berron Sonia del , Miklós Wenczl , Katalin Molnár , Katalin Hideghéty , Alexander Lossos , Linde Myra van , Ana Levy , Rosemary Harrup , William Patterson , Zarnie Lwin , Sith Sathornsumetee , E-Jian Lee , Jih-Tsun Ho , Steven Emmons , J. Paul Duic , Spencer Shao , Hani Ashamalla , Michael Weaver , Jose Lutzky , Nicholas Avgeropoulos , Wahid Hanna , Mukund Nadipuram , Gary Cecchi , Robert O'Donnell , Susan Pannullo , Jennifer Carney , Mark Hamilton , Mary MacNeil , Ronald Beaney , Michel Fabbro , Oliver Schnell , Rainer Fietkau , Guenther Stockhammer , Bela Malinova , Karel Odrazka , Martin Sames , Gil Miguel Gil , Evangelia Razis , Konstantin Lavrenkov , Guillermo Castro , Francisco Ramirez , Clarissa Baldotto , Fabiana Viola , Suzana Malheiros , Jason Lickliter , Stanislaw Gauden , Arunee Dechaphunkul , Iyavut Thaipisuttikul , Ziad Thotathil , Hsin-I Ma , Wen-Yu Cheng , Chin-Hong Chang , Fernando Salas , Pierre-Yves Dietrich , Christoph Mamot , Lakshmi Nayak , Shona Nag
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Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet haemocyanin. In the ACT IV study, we aimed to assess whether or not the addition of rindopepimut to standard chemotherapy is able to improve survival in patients with EGFRvIII-positive glioblastoma.
中文翻译：
替诺唑胺与替莫唑胺联合用于新诊断为EGFRvIII表达的成胶质细胞瘤（ACT IV）的患者：一项随机，双盲的国际3期临床试验。
Rindopepimut（也称为CDX-110），一种针对EGFR缺失突变EGFRvIII的疫苗，由与匙孔血蓝蛋白缀合的EGFRvIII特异性肽组成。在ACT IV研究中，我们旨在评估在标准化疗中添加rindopepimut是否能够提高EGFRvIII阳性胶质母细胞瘤患者的生存率。
更新日期：2017-08-23
中文翻译：
替诺唑胺与替莫唑胺联合用于新诊断为EGFRvIII表达的成胶质细胞瘤（ACT IV）的患者：一项随机，双盲的国际3期临床试验。
Rindopepimut（也称为CDX-110），一种针对EGFR缺失突变EGFRvIII的疫苗，由与匙孔血蓝蛋白缀合的EGFRvIII特异性肽组成。在ACT IV研究中，我们旨在评估在标准化疗中添加rindopepimut是否能够提高EGFRvIII阳性胶质母细胞瘤患者的生存率。
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