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Photoinduced Regioselective Lactonization of ortho-Iodobenzoic Acids with Alkenes: Synthesis of 3,4-Dihydroisocoumarin Derivatives
Synlett ( IF 2 ) Pub Date : 2017-08-22 , DOI: 10.1055/s-0036-1588541
Chao Yang , Wujiong Xia , Xiao Zhang , Binbin Huang

A photoinduced strategy for the synthesis of a variety of 3,4-dihydroisocoumarins has been realized. The reactions proceeded from ortho -iodobenzoic acids and alkenes through a photodehalogenative lactonization with NaHCO 3 as the only additive in dimethyl sulfoxide (DMSO) to provide the desired products in moderate to good yields. This method offers a simple, mild, and environmentally friendly route to 3,4-dihydroisocoumarin derivatives.

中文翻译:

邻碘苯甲酸与烯烃的光诱导区域选择性内酯化:3,4-二氢异香豆素衍生物的合成

已经实现了合成多种 3,4-二氢异香豆素的光诱导策略。该反应从邻碘苯甲酸和烯烃通过光脱卤内酯化反应进行,NaHCO 3 作为二甲基亚砜 (DMSO) 中的唯一添加剂,以中等至良好的收率提供所需的产物。该方法为 3,4-二氢异香豆素衍生物提供了一种简单、温和且环保的途径。
更新日期:2017-08-22
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