Spurred on by recent progress in nanotechnology and precision medicine, smart drug carriers are entering an entirely new era. Smart drug carriers have been widely studied in recent years as a result of their ability to control drug release under different microenvironments (such as pH, redox, and enzyme) in vivo. Host–guest interactions based on cyclodextrins have proven to be an efficient tool for fabricating smart drug carriers. Because of the application of host–guest interactions, many kinds of biological molecules or supramolecular building blocks can combine into an organic whole at the molecular level. In this review, the features, mechanisms of action, and potent applications of biological stimuli-responsive drug carriers based on cyclodextrins are discussed. In addition, some personal perspectives on this field are presented.

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基于环糊精的生物刺激响应载体，用于智能和精密医学

在纳米技术和精密医学的最新进展的推动下，智能药物载体正在进入一个全新的时代。近年来，由于智能药物载体具有在体内不同微环境（例如pH，氧化还原和酶）下控制药物释放的能力，因此对其进行了广泛的研究。。事实证明，基于环糊精的客体相互作用是制造智能药物载体的有效工具。由于宿主-客体相互作用的应用，许多种类的生物分子或超分子构件可以在分子水平上组合成有机整体。在这篇综述中，讨论了基于环糊精的生物刺激响应药物载体的特征，作用机理和有效应用。此外，还介绍了该领域的一些个人观点。