MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin†,Biomaterials Science

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MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin†
Biomaterials Science ( IF 6.6 ) Pub Date : 2017-06-13 00:00:00 , DOI: 10.1039/c7bm00431a
Bo Wu _{1,

2,

3,

4,

5} , Xiao-Qi Li _{1,

2,

3,

4,

5} , Tong Huang _{5,

6,

7,

8} , Shu-Ting Lu _{1,

2,

3,

4,

5} , Bing Wan _{1,

9,

10,

11,

12} , Ru-Fang Liao _{1,

2,

3,

4,

5} , Yu-Shuang Li _{1,

2,

3,

4,

5} , Aju Baidya _{1,

2,

3,

4,

5} , Qing-Yun Long _{1,

2,

3,

4,

5} , Hai-Bo Xu _{1,

2,

3,

4,

5}

Affiliation

Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(III)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.

中文翻译：

MRI指导的Gd / Pt双官能化卟啉的肿瘤化学光动力疗法†

卟啉衍生物已广泛应用于MR成像和光动力癌症治疗。我们在这里报告了一种新型的Gd / Pt双官能化卟啉衍生物（Gd / Pt-P1），用于MRI指导的化学光动力癌症治疗。由四（4-吡啶基）卟啉（P1）经与顺铂和g（Gd（III））的逐步配位制备Gd / Pt-P1 。Gd / Pt-P1在体内显示出特别高的协同化学光动力学抗肿瘤作用，肿瘤抑制率（TIR）为96.6％，并且具有出色的MR成像性能。

更新日期：2017-06-13

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