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Novel nanosensing technologies for exosome detection and profiling
Lab on a Chip ( IF 6.1 ) Pub Date : 2017-07-18 00:00:00 , DOI: 10.1039/c7lc00247e
Hyungsoon Im 1, 2, 3, 4, 5 , Kyungheon Lee 1, 2, 3, 4 , Ralph Weissleder 1, 2, 3, 4, 5 , Hakho Lee 1, 2, 3, 4, 5 , Cesar M. Castro 1, 2, 3, 4, 6
Affiliation  

Exosomes have recently emerged as highly promising cancer biomarkers because they are abundant in biofluids, carry proteins and RNA reflecting their originating cells and are stable over weeks. Beyond abundance and stability, detailed exosome analyses could be clinically useful for diagnosing and profiling cancers. Despite their clinical potential, simple, reliable and sensitive approaches for rapidly quantifying exosomes and their molecular information has been challenging. Therefore, there is a clear need to develop next-generation sensing technologies for exosome detection and analysis. In this critical review, we will describe three nanotechnology sensing platforms developed for analysis of exosomal proteins and RNAs directly from clinical specimens and discuss future development to facilitate their translation into routine clinical use.

中文翻译:

用于外泌体检测和分析的新型纳米传感技术

外来体最近已成为很有前途的癌症生物标志物,因为它们的生物流体丰富,携带反映其起源细胞的蛋白质和RNA,并在数周内保持稳定。除了丰度和稳定性之外,详细的外泌体分析在临床上还可用于诊断和分析癌症。尽管具有临床潜力,但快速,定量,可靠,灵敏的方法可快速定量外泌体及其分子信息。因此,显然需要开发用于外泌体检测和分析的下一代传感技术。在这篇重要的综述中,我们将描述三个直接用于从临床标本中分析外泌体蛋白质和RNA的纳米技术传感平台,并讨论未来的发展以促进将其转化为常规临床用途。
更新日期:2017-08-22
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