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DMSO Chemically Alters Cell Membranes to Slow Exocytosis and Increase the Fraction of Partial Transmitter Released
ChemBioChem ( IF 3.2 ) Pub Date : 2017-08-21 , DOI: 10.1002/cbic.201700410
Soodabeh Majdi 1 , Neda Najafinobar 2 , Johan Dunevall 2 , Jelena Lovric 2 , Andrew G. Ewing 1, 2
Affiliation  

Permitting neurotransmitter passage: Dimethyl sulfoxide (DMSO) is commonly used in biological studies and as a vehicle for drug delivery. This study shows that DMSO chemically affects the permeability of cell membranes and possibly alters proteins involved in opening or closing pores during vesicle fusion, leading to a larger fraction of catecholamine being released from each vesicle.
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中文翻译:

DMSO化学改变细胞膜以减慢胞吐作用并增加释放的部分递质的分数

允许神经递质通过:二甲基亚砜(DMSO)通常用于生物学研究,并用作药物输送的载体。这项研究表明,DMSO在化学上影响细胞膜的通透性,并可能改变囊泡融合过程中与打开或关闭孔有关的蛋白质,从而导致从每个囊泡中释放出较大比例的儿茶酚胺。
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更新日期:2017-08-21
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