An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase—an enzyme that is nonessential for in vitro growth—has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.

中文翻译：

---

药物开发：抑制新陈代谢

结核分枝杆菌色氨酸合酶的一种变构抑制剂具有强大的抗菌活性，该抑制剂对于体外生长而言是非必需的酶，揭示了潜在的抗菌靶标范围扩大以及新抑制剂的更大化学空间。