Posttranslational modifications are covalent changes made to proteins that typically alter the function or location of the protein. AMPylation is an emerging posttranslational modification that involves the addition of adenosine monophosphate (AMP) to a protein. Like other, more well-studied posttranslational modifications, AMPylation is predicted to regulate the activity of the modified target proteins. However, the scope of this modification both in bacteria and in eukaryotes remains to be fully determined. In this review, we provide an up to date overview of the known AMPylating enzymes, the regulation of these enzymes, and the effect of this modification on target proteins.

中文翻译：

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涉及AMPylation和deAMPylation的酶

翻译后修饰是对蛋白质进行的共价改变，通常会改变蛋白质的功能或位置。AMPylation是一种新兴的翻译后修饰，涉及将单磷酸腺苷（AMP）添加到蛋白质中。像其他更深入研究的翻译后修饰一样，AMPylation有望调节修饰的靶蛋白的活性。但是，这种修饰在细菌和真核生物中的范围仍有待完全确定。在这篇综述中，我们提供了已知AMPylating酶的最新概况，这些酶的调节以及这种修饰对靶蛋白的影响。