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Physiological functions of programmed DNA breaks in signal-induced transcription
Nature Reviews Molecular Cell Biology ( IF 112.7 ) Pub Date : 2017-05-24 , DOI: 10.1038/nrm.2017.43
Janusz Puc 1 , Aneel K Aggarwal 2 , Michael G Rosenfeld 3
Affiliation  

The idea that signal-dependent transcription might involve the generation of transient DNA nicks or even breaks in the regulatory regions of genes, accompanied by activation of DNA damage repair pathways, would seem to be counterintuitive, as DNA damage is usually considered harmful to cellular integrity. However, recent studies have generated a substantial body of evidence that now argues that programmed DNA single- or double-strand breaks can, at least in specific cases, have a role in transcription regulation. Here, we discuss the emerging functions of DNA breaks in the relief of DNA torsional stress and in promoter and enhancer activation.



中文翻译:

信号诱导转录中程序性 DNA 断裂的生理功能

信号依赖性转录可能涉及基因调控区域中瞬时 DNA 切口甚至断裂的产生,伴随着 DNA 损伤修复途径的激活,这一想法似乎是违反直觉的,因为 DNA 损伤通常被认为对细胞完整性有害. 然而,最近的研究已经产生了大量证据,现在认为程序性 DNA 单链或双链断裂可以,至少在特定情况下,在转录调节中起作用。在这里,我们讨论了 DNA 断裂在缓解 DNA 扭转应力以及启动子和增强子激活中的新兴功能。

更新日期:2017-08-18
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