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Technologies for Analysis of Circulating Tumor DNA: Progress and Promise
Trends in Analytical Chemistry ( IF 13.1 ) Pub Date : 2017-08-12 , DOI: 10.1016/j.trac.2017.08.004
Zhen Zou , Peng Qi , Zhihe Qing , Jing Zheng , Sheng Yang , Weiju Chen , Ronghua Yang

Circulating tumor DNA (ctDNA) isolated from peripheral blood has recently been shown to be a biomarker to detect gene mutations for the diagnosis, treatment, and prognosis of cancer. Utilizing ctDNA as the liquid biopsy has significant potential to pave the way toward a better understanding of cancer at the molecular level and improve patient outcomes in the future. Over the past decades, a large number of efforts have been devoted to the development of valid methods for analyzing ctDNA, which provide researchers and clinicians a variety of tools to detect and monitor tumors. In this review, we displayed an overview of current representative technologies for the detection of ctDNA and discuss recent technical advancements. Then, the challenges and outlooks in this promising field are featured on the basis of its current development.

中文翻译:

循环肿瘤DNA分析技术:进展与前景

从外周血中分离出来的循环肿瘤DNA(ctDNA)最近被证明是检测基因突变以诊断,治疗和预后癌症的生物标志物。将ctDNA用作液体活检具有巨大的潜力,为在分子水平上更好地了解癌症和将来改善患者预后铺平道路。在过去的几十年中,人们一直致力于开发有效的ctDNA分析方法,这些方法为研究人员和临床医生提供了多种检测和监测肿瘤的工具。在这篇综述中,我们展示了用于检测ctDNA的当前代表性技术的概述,并讨论了最新的技术进步。然后,根据其当前的发展,对这一有前途的领域提出挑战和展望。
更新日期:2017-08-18
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