当前位置: X-MOL 学术Ann. Review Paleopathol. Mech. Disease › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
Annual Review of Pathology: Mechanisms of Disease ( IF 36.2 ) Pub Date : 2017-01-30 00:00:00 , DOI: 10.1146/annurev-pathol-052016-100322
Silvia Affo 1 , Le-Xing Yu 1 , Robert F. Schwabe 1
Affiliation  

Liver cancer is the second leading cause of cancer mortality worldwide, causing more than 700,000 deaths annually. Because of the wide landscape of genomic alterations and limited therapeutic success of targeting tumor cells, a recent focus has been on better understanding and possibly targeting the microenvironment in which liver tumors develop. A unique feature of liver cancer is its close association with liver fibrosis. More than 80% of hepatocellular carcinomas (HCCs) develop in fibrotic or cirrhotic livers, suggesting an important role of liver fibrosis in the premalignant environment (PME) of the liver. Cholangiocarcinoma (CCA), in contrast, is characterized by a strong desmoplasia that typically occurs in response to the tumor, suggesting a key role of cancer-associated fibroblasts (CAFs) and fibrosis in its tumor microenvironment (TME). Here, we discuss the functional contributions of myofibroblasts, CAFs, and fibrosis to the development of HCC and CCA in the hepatic PME and TME, focusing on myofibroblast- and extracellular matrix–associated growth factors, fibrosis-associated immunosuppressive pathways, as well as mechanosensitive signaling cascades that are activated by increased tissue stiffness. Better understanding of the role of myofibroblasts in HCC and CCA development and progression may provide the basis to target these cells for tumor prevention or therapy.

中文翻译:


癌症相关的成纤维细胞和纤维化在肝癌中的作用

肝癌是全球第二大导致癌症死亡的主要原因,每年造成700,000多人死亡。由于基因组改变的广阔前景以及靶向肿瘤细胞的有限治疗成功,最近的焦点一直集中在更好地理解并可能靶向发展肝肿瘤的微环境上。肝癌的独特特征是它与肝纤维化密切相关。超过80%的肝细胞癌(HCC)在纤维化或肝硬化的肝中发展,表明肝纤维化在肝脏的癌前环境(PME)中起着重要的作用。相反,胆管癌(CCA)的特征是强烈的异形增生,通常在对肿瘤的反应中发生,提示癌症相关的成纤维细胞(CAF)和纤维化在其肿瘤微环境(TME)中起着关键作用。在这里,我们讨论了成肌纤维细胞,CAF和纤维化对肝PME和TME中HCC和CCA发育的功能性贡献,重点讨论了与成纤维细胞和细胞外基质相关的生长因子,与纤维化相关的免疫抑制途径以及机械敏感性信号由增强的组织刚度激活的级联反应。更好地了解成肌纤维细胞在HCC和CCA发育和进程中的作用,可以为靶向这些细胞进行肿瘤预防或治疗提供基础。以及由增加的组织刚度激活的机械敏感信号级联。更好地了解成肌纤维细胞在HCC和CCA发育和进程中的作用,可以为靶向这些细胞进行肿瘤预防或治疗提供基础。以及由增加的组织刚度激活的机械敏感信号级联。更好地了解成肌纤维细胞在HCC和CCA发育和进程中的作用,可以为靶向这些细胞进行肿瘤预防或治疗提供基础。

更新日期:2017-01-30
down
wechat
bug