Annual Review of Immunology ( IF 29.7 ) Pub Date : 2017-04-26 00:00:00 , DOI: 10.1146/annurev-immunol-041015-055354 Gwendalyn J. Randolph 1 , Stoyan Ivanov 1 , Bernd H. Zinselmeyer 1 , Joshua P. Scallan 2
The lymphatic vasculature is not considered a formal part of the immune system, but it is critical to immunity. One of its major roles is in the coordination of the trafficking of antigen and immune cells. However, other roles in immunity are emerging. Lymphatic endothelial cells, for example, directly present antigen or express factors that greatly influence the local environment. We cover these topics herein and discuss how other properties of the lymphatic vasculature, such as mechanisms of lymphatic contraction (which immunologists traditionally do not take into account), are nonetheless integral in the immune system. Much is yet unknown, and this nascent subject is ripe for exploration. We argue that to consider the impact of lymphatic biology in any given immunological interaction is a key step toward integrating immunology with organ physiology and ultimately many complex pathologies.
中文翻译:
淋巴系统:免疫中的整体作用
淋巴管系统不被认为是免疫系统的正式组成部分,但对免疫至关重要。它的主要作用之一是协调抗原和免疫细胞的运输。但是,免疫的其他作用正在兴起。例如,淋巴管内皮细胞直接呈递抗原或表达极大影响局部环境的因子。我们在本文中涵盖了这些主题,并讨论了淋巴管系统的其他特性,例如淋巴收缩的机制(免疫学家传统上并未考虑在内)如何在免疫系统中不可或缺。许多事情还未知,这个新兴的主题已经成熟,可以探索了。