Enones in which the carbon–carbon double bond is part of the pharmacologically important 2 H -chromene (2 H -1-benzopyran) nucleus undergo asymmetric copper-catalyzed 1,2-addition of Grignard reagents. High yields and enantiomeric excesses up to 84% are obtained and access to these novel enantio-enriched tertiary alcohols is provided.

中文翻译：

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铜催化不对称 1,2-加成格氏试剂到 3-酰基 2H-色烯

其中碳 - 碳双键是药理学上重要的 2 H -色烯（2 H -1-苯并吡喃）核的一部分的烯酮经历不对称铜催化的格氏试剂的 1,2-加成。获得了高达 84% 的高产率和对映体过量，并提供了获得这些新型对映体富集的叔醇的途径。