Sonogashira reactions of steroids have been studied. The reaction of α-estron-16-methylidenyloxy triflate with various alkynes afforded novel alkynylvinylidene steroids. The reactions proceeded in good to quantitative yields, with excellent E -selectivity and with a broad synthetic scope.

中文翻译：

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钯催化的 16-(羟基亚甲基)-3-甲氧基-α-雌酮的 Sonogashira 反应

研究了类固醇的 Sonogashira 反应。α-estron-16-methylidenyloxy triflate 与各种炔烃的反应提供了新型炔基亚乙烯基类固醇。反应以良好的定量产率进行，具有优异的 E 选择性和广泛的合成范围。