A simple capillary zone electrophoresis (CZE) method was developed to achieve the rapid enantiomeric separation of a set of acidic drugs using streptomycin as chiral selector. The enantiomers of 5 chiral phenyl-containing acidic pharmaceutical compounds were separated excellently by CE using an uncoated silica capillary. Several experimental parameters such as the concentration of streptomycin, buffer concentration and pH, running voltage, and capillary temperature were all investigated systematically in order to optimize the chiral separation. All analytes were got baseline separation within 10 min. And the results showed that streptomycin can be used as a chiral selector to the enantioseparation of five acidic drugs by CZE method.

开发了一种简单的毛细管区带电泳（CZE）方法，以使用链霉素作为手性选择剂来快速分离一组酸性药物的对映异构体。使用未涂覆的二氧化硅毛细管通过CE可以出色地分离5种手性苯基酸性药物化合物的对映异构体。为了优化手性分离，系统地研究了几个实验参数，例如链霉素的浓度，缓冲液的浓度和pH，运行电压和毛细管温度。在10分钟内将所有分析物进行基线分离。结果表明，链霉素可以作为手性选择剂，通过CZE法对5种酸性药物进行对映体分离。