Patients with diabetes mellitus are prone to develop refractory wounds. They exhibit reduced synthesis and levels of circulating hydrogen sulfide (H₂S), which is an ephemeral gaseous molecule. Physiologically, H₂S is an endogenous gasotransmitter with multiple biological functions. An emulsion method is utilized to prepare a microparticle system that comprises phase-change materials with a nearly constant temperature of phase transitions to encapsulate sodium hydrosulfide (NaHS), a highly water-labile H₂S donor. An emulsion technique that can minimize the loss of water-labile active compounds during emulsification must be developed. The as-prepared microparticles (NaHS@MPs) provide an in situ depot for the sustained release of exogenous H₂S under physiological conditions. The sustained release of H₂S promotes several cell behaviors, including epidermal/endothelial cell proliferation and migration, as well as angiogenesis, by extending the activation of cellular ERK1/2 and p38, accelerating the healing of full-thickness wounds in diabetic mice. These experimental results reveal the strong potential of NaHS@MPs for the sustained release of H₂S for the treatment of diabetic wounds.

中文翻译：

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包含相变材料的原位储库，该相变材料可以持续释放气体递质H ₂ S以治疗糖尿病伤口

糖尿病患者容易出现难治性伤口。它们显示出减少的合成和循环硫化氢（H ₂ S）的水平，硫化氢是一种短暂的气态分子。在生理上，H ₂ S是具有多种生物学功能的内源性气体递质。利用乳液法制备了一种微粒系统，该微粒系统包含相变材料，其相变温度几乎恒定，以包裹高度不稳定的H ₂ S供体硫化氢钠（NaHS）。必须开发一种乳化技术，该技术可以将乳化过程中对水不稳定的活性化合物的损失降至最低。制备的微粒（NaHS @ MPs）提供了原位在生理条件下持续释放外源H ₂ S的仓库。H ₂ S的持续释放通过延长细胞ERK1 / 2和p38的激活，加速糖尿病小鼠全层伤口的愈合，促进了几种细胞行为，包括表皮/内皮细胞的增殖和迁移以及血管生成。这些实验结果表明，NaHS @ MPs具有持续释放H ₂ S的强大潜力，可用于治疗糖尿病伤口。