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RGD peptide-modified fluorescent gold nanoclusters as highly efficient tumor-targeted radiotherapy sensitizers
Biomaterials ( IF 14.0 ) Pub Date : 2017-08-16 , DOI: 10.1016/j.biomaterials.2017.08.017
Guohai Liang , Xudong Jin , Shuxu Zhang , Da Xing

Radiotherapy is a leading treatment approach of cancer therapy. While it is effective in killing tumor cells, it can also cause serious damage to surrounding normal tissue. Targeted radiotherapy with gold nanoparticle-based radiosensitizers is actively being investigated, and considered as a promising means to enhance the efficacy of radiotherapy against tumors under a relatively low and safe radiation dose. In this work, we report a green and one-step strategy to synthesize fluorescent gold nanoclusters by using a commercialized cyclic arginine-glycine-aspartic acid (c(RGDyC)) peptide as the template. The nanoclusters inherit special properties of both the Au core (red/NIR fluorescence emission and strong radiosensitizing effect) and c(RGDyC) shell (active cancer cell-targeting ability and good biocompatibility), and can be applied as fluorescent probes to stain αvβ3 integrin-positive cancer cells, as well as radiosensitizing agents to boost the killing efficacy of radiotherapy. Our data suggest that the as-designed gold nanoclusters have excellent biocompatibility, bright red/NIR fluorescence, active tumor targeting property, and strong radiosensitizing effect, making them highly promising towards potential clinical translation.

中文翻译:

RGD肽修饰的荧光金纳米簇作为高效的肿瘤靶向放射治疗敏化剂

放射疗法是癌症疗法的主要治疗方法。虽然它可以有效杀死肿瘤细胞,但也会对周围的正常组织造成严重损害。用金纳米粒子为基础的放射增敏剂的靶向放疗正在积极研究中,被认为是在相对较低和安全的辐射剂量下增强放疗抗肿瘤功效的有前途的手段。在这项工作中,我们报告了一种绿色的一步法,以商业化的环状精氨酸-甘氨酸-天冬氨酸(c(RGDyC))肽为模板来合成荧光金纳米簇。纳米簇继承了Au核(红色/ NIR荧光发射和强放射增敏作用)和c(RGDyC)壳的特殊性质(活性癌细胞靶向能力和良好的生物相容性),v β 3整联蛋白阳性癌细胞,以及放射增敏剂以提高放射治疗的杀灭效力。我们的数据表明,设计好的金纳米簇具有出色的生物相容性,鲜红色/ NIR荧光,活跃的肿瘤靶向特性和强大的放射增敏作用,使其对于潜在的临床翻译具有很高的前景。
更新日期:2017-08-17
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