Isocyanic acid (ICA) is one of the most abundant isocyanates formed during thermal decomposition of polyurethane (PUR), and other nitrogen containing polymers. Hot-work, such as flame cutting, forging, grinding, turning and welding may give rise to thermal decomposition of said polymers potentially forming significant amounts of ICA. A newly launched dry denuder sampler for airborne isocyanates using di-n-butylamine (DBA) demonstrated build-up of background ICA-DBA over time. Build-up of background ICA-DBA was not observed when stored at inert conditions (Ar atmosphere) for 84 days. Thus, freshly prepared denuders were used. The sampling efficiency of ICA using freshly prepared denuder samplers (0.2 L min⁻¹), impinger + filter samplers (0.5 L min⁻¹) using DBA and 1-(2-methoxyphenyl) piperazine (2MP)-impregnated filter cassette samplers (1 L min⁻¹) was investigated. PTR-MS measurements of ICA were used as a quantitative reference. Dynamically generated standard ICA atmospheres covered the range 5.6 to 640 ppb at absolute humidities (AH) 4.0 and 16 g m⁻³. Recovered ICA was found to be 73–115% (denuder), 89–115% (impinger + filter) and 62–100% (2MP filter cassette). The method limit of detection (LOD) was equal to an amount of ICA of 24 ng (denuder), 8.9 ng (impinger + filter) and 9.4 ng (2MP filter cassette). The PTR-MS LOD for ICA was 1.8 and 2.8 ppb in atmospheres with an AH of 4 and 16 g m⁻³. Denuder samplers were used for personal (n = 176) and stationary (n = 31) air sampling during hot-work at six industrial sites (n = 23 workers). ICA was detected above method LOD in 66% and 58% of the personal and stationary samples, respectively. ICA workroom air concentrations were determined to be 1.8–320 ppb (median 12 ppb) (personal samples), and 1.5–44 ppb (median 6.6 ppb) (stationary samples).

中文翻译：

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用于确定异氰酸的空气采样器的比较及其在工作环境暴露评估中的适用性

异氰酸（ICA）是聚氨酯（PUR）和其他含氮聚合物热分解过程中形成的最丰富的异氰酸酯之一。诸如火焰切割，锻造，研磨，车削和焊接之类的热加工可能引起所述聚合物的热分解，从而潜在地形成大量的ICA。新型使用二正丁胺（DBA）推出的用于空气中异氰酸酯的干式剥蚀仪采样器证明了背景ICA-DBA随着时间的推移逐渐积累。在惰性条件下（Ar气氛）存放84天时，未观察到背景ICA-DBA的积累。因此，使用了新鲜制备的剥蚀剂。使用新鲜制备的剥蚀器采样器（0.2 L min ^-1），冲击器+过滤器采样器（0.5 L min ^-1）的ICA采样效率）使用DBA和1-（2-甲氧基苯基）哌嗪（2MP）浸渍的滤盒取样器（1 L min ^-1）进行了研究。ICA的PTR-MS测量用作定量参考。动态生成的标准ICA大气在绝对湿度（AH）4.0和16 gm ^-3时覆盖5.6到640 ppb的范围。回收的ICA被发现为73–115％（denuder），89–115％（撞击器+过滤器）和62–100％（2MP过滤器盒）。方法的检出限（LOD）等于ICA的量为24 ng（裸露器），8.9 ng（撞击器+过滤器）和9.4 ng（2MP滤盒）。在AH为4和16 gm ^-3的大气中，ICA的PTR-MS LOD为1.8和2.8 ppb 。Denuder采样器用于个人（n = 176）和固定式（n= 31）在六个工业场所（n = 23名工人）进行热加工时进行空气采样。ICA检出率高于方法LOD，分别有66％和58％的个人和固定样本。ICA工作间的空气浓度确定为1.8–320 ppb（中值12 ppb）（个人样本）和1.5–44 ppb（中值6.6 ppb）（固定样本）。