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The interplay of epigenetic marks during stem cell differentiation and development
Nature Reviews Genetics ( IF 42.7 ) Pub Date : 2017-08-14 , DOI: 10.1038/nrg.2017.57
Yaser Atlasi , Hendrik G. Stunnenberg

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly reshaped during early development and differentiation. Epigenetic modification of chromatin provides the necessary plasticity for cells to respond to environmental and positional cues, and enables the maintenance of acquired information without changing the DNA sequence. The mechanisms involve, among others, chemical modifications of chromatin, changes in chromatin constituents and reconfiguration of chromatin interactions and 3D structure. New advances in genome-wide technologies have paved the way towards an integrative view of epigenome dynamics during cell state transitions, and recent findings in embryonic stem cells highlight how the interplay between different epigenetic layers reshapes the transcriptional landscape.



中文翻译:

表观遗传标记在干细胞分化和发育过程中的相互作用

染色质是表观遗传调控的模板,是一种高度动态的实体,在早期发育和分化过程中会不断重塑。染色质的表观遗传修饰为细胞响应环境和位置提示提供了必要的可塑性,并能够在不改变DNA序列的情况下维持获得的信息。该机制尤其涉及染色质的化学修饰,染色质成分的变化以及染色质相互作用和3D结构的重新配置。全基因组技术的新进展为细胞状态转换过程中表观基因组动力学的综合观点铺平了道路,最近在胚胎干细胞中的发现凸显了不同表观遗传层之间的相互作用如何重塑转录态势。

更新日期:2017-08-14
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