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Pseudomonas predators: understanding and exploiting phage–host interactions
Nature Reviews Microbiology ( IF 88.1 ) Pub Date : 2017-06-26 00:00:00 , DOI: 10.1038/nrmicro.2017.61
Jeroen De Smet , Hanne Hendrix , Bob G. Blasdel , Katarzyna Danis-Wlodarczyk , Rob Lavigne

Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant pathogen Pseudomonas syringae. The bacteriophages that infect Pseudomonas spp. mirror the widespread and diverse nature of their hosts. Therefore, Pseudomonas spp. and their phages are an ideal system to study the molecular mechanisms that govern virus–host interactions. Furthermore, phages are principal catalysts of host evolution and diversity, which directly affects the ecological roles of environmental and pathogenic Pseudomonas spp. Understanding these interactions not only provides novel insights into phage biology but also advances the development of phage therapy, phage-derived antimicrobial strategies and innovative biotechnological tools that may be derived from phage–bacteria interactions.

中文翻译:

假单胞菌天敌:了解和利用噬菌体与宿主的相互作用

假单胞菌属的物种在各种各样的生态位中成长,并且包括重要的病原体,例如人类病原体铜绿假单胞菌和植物病原体丁香假单胞菌。感染假单胞菌的噬菌体。反映了其主人的广泛而多样的性质。因此,假单胞菌属。它们的噬菌体是研究控制病毒与宿主相互作用的分子机制的理想系统。此外,噬菌体是宿主进化和多样性的主要催化剂,直接影响环境和致病性假单胞菌的生态作用。spp。了解这些相互作用不仅为噬菌体生物学提供了新颖的见解,而且还促进了噬菌体疗法,噬菌体衍生的抗微生物策略以及可从噬菌体-细菌相互作用中获得的创新生物技术工具的发展。
更新日期:2017-08-14
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