A well‐defined amphiphilic triblock copolymer, poly[(ethylene glycol)methyl ether]‐block‐poly(N,N‐dimethylamino ethyl methacrylate‐co‐2,2,2‐trifluoroethyl methacrylate)‐block‐poly(4‐(4‐methoxy‐phenylazo)phenoxy methacrylate) (PEG‐b‐P(DMAEMA‐co‐TFEMA)‐b‐PMEPPMA), is successfully synthesized by stepwise atom transfer radical polymerization. Owing to its amphiphilic nature, PEG‐b‐P(DMAEMA‐co‐TFEMA)‐b‐PMEPPMA can self‐assemble into vesicles in aqueous solution and exhibits a reversible triple‐responsive behavior toward CO₂, O₂, and light stimuli. More importantly, such vesicles can exhibit a controlled “breathing” behavior via external stimuli due to their suitable chemical structure and stimuli responsiveness. Consequently, these vesicles can be employed as nanocarriers for rate‐tunable controlled release via adjustment of their membrane permeability by a single stimulus or various stimuli combinations.

中文翻译：

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从三嵌段共聚物中“呼吸” CO2，O2和光响应性囊泡，实现速率可调的控释

A-良好定义的两亲性三嵌段共聚物，聚[（乙二醇）甲基醚] -嵌段-聚（N，N-二甲基氨基乙基甲基丙烯酸酯共-2,2,2-三氟乙基甲基丙烯酸酯） -嵌段-聚（4-（4-通过逐步原子转移自由基聚合成功合成了（甲氧基苯基偶氮）苯氧基甲基丙烯酸酯（PEG- b -P（DMAEMA- co - TFEMA）b- PMEPPMA）。由于具有两亲性质，PEG- b -P（DMAEMA- co - TFEMA）-b -PMEPPMA可以在水溶液中自组装成囊泡，并且对CO ₂，O ₂表现出可逆的三重响应行为和光刺激。更重要的是，由于其合适的化学结构和刺激响应性，此类囊泡可通过外部刺激表现出受控的“呼吸”行为。因此，这些囊泡可以用作纳米载体，通过单个刺激或多种刺激组合调节其膜的通透性，从而实现速率可调的控释。