当前位置: X-MOL 学术Lancet › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Clinical presentation and management of dyskinetic cerebral palsy.
The Lancet ( IF 168.9 ) Pub Date : 2017-09-01 , DOI: 10.1016/s1474-4422(17)30252-1
Elegast Monbaliu , Kate Himmelmann , Jean-Pierre Lin , Els Ortibus , Laura Bonouvrié , Hilde Feys , R Jeroen Vermeulen , Bernard Dan

Cerebral palsy is the most frequent cause of severe physical disability in childhood. Dyskinetic cerebral palsy (DCP) is the second most common type of cerebral palsy after spastic forms. DCP is typically caused by non-progressive lesions to the basal ganglia or thalamus, or both, and is characterised by abnormal postures or movements associated with impaired tone regulation or movement coordination. In DCP, two major movement disorders, dystonia and choreoathetosis, are present together most of the time. Dystonia is often more pronounced and severe than choreoathetosis, with a major effect on daily activity, quality of life, and societal participation. The pathophysiology of both movement disorders is largely unknown. Some emerging hypotheses are an imbalance between indirect and direct basal ganglia pathways, disturbed sensory processing, and impaired plasticity in the basal ganglia. Rehabilitation strategies are typically multidisciplinary. Use of oral drugs to provide symptomatic relief of the movement disorders is limited by adverse effects and the scarcity of evidence that the drugs are effective. Neuromodulation interventions, such as intrathecal baclofen and deep brain stimulation, are promising options.

中文翻译:

运动障碍性脑瘫的临床表现和处理。

脑瘫是儿童严重肢体残疾的最常见原因。运动障碍性脑瘫(DCP)是仅次于痉挛形式的第二大最常见的脑瘫类型。DCP通常由基底节或丘脑或两者的非进行性病变引起,其特征是异常姿势或动作与音调调节或动作协调性受损有关。在DCP中,大多数情况下同时存在两种主要的运动障碍,肌张力障碍和胆汁淤积症。肌张力障碍通常比舞蹈性运动症更为明显和严重,对日常活动,生活质量和社会参与具有重大影响。两种运动障碍的病理生理学在很大程度上是未知的。一些新出现的假说是间接和直接的基底神经节通路之间的不平衡,感觉过程的干扰,并损害了基底神经节的可塑性。康复策略通常是多学科的。口服药物提供运动障碍的症状缓解受到不良反应和药物有效证据不足的限制。鞘内注射巴氯芬和深层脑刺激等神经调节干预措施是有前途的选择。
更新日期:2017-08-10
down
wechat
bug