Findings from longitudinal follow-up studies in patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) have shown that most patients will eventually develop the synucleinopathies Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Neuroinflammation in the form of microglial activation is present in synucleinopathies and is a potential therapeutic target to halt or delay the neurodegenerative process. We aimed to investigate whether neuroinflammation is present in patients with IRBD and its possible relation to nigrostriatal dopamine function.

中文翻译：

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特发性快速眼动睡眠行为障碍患者神经炎症的评估：一项病例对照研究。

对患有特发性快速眼动睡眠行为障碍（IRBD）的患者进行的纵向随访研究发现，大多数患者最终会发展为帕金森氏病，路易体痴呆或多系统萎缩症。小胶质细胞活化形式的神经炎症存在于突触核蛋白病中，并且是阻止或延缓神经变性过程的潜在治疗靶标。我们旨在调查IRBD患者中是否存在神经炎症及其与黑质纹状体多巴胺功能的可能关系。