Neuroinflammation in neurodegenerative diseases generally refers to a chronic immune response in the CNS, in which innate immune cells such as microglia and astrocytes are responsible for robust inflammatory responses and neuronal death. However, each neurodegenerative disease also has a preclinical period, during which potentially harmful inflammatory events might already be happening. With the advent of disease-modifying drugs, early detection of abnormal signals from the brain milieu during the preclinical phase is important because diagnostic symptoms, once developed, are so relentless that few therapeutic countermeasures are left for clinicians to use.

中文翻译：

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成像神经炎症以监测α-突触核蛋白病

神经退行性疾病中的神经炎症通常是指中枢神经系统中的慢性免疫反应，其中先天性免疫细胞（例如小胶质细胞和星形胶质细胞）负责强烈的炎症反应和神经元死亡。但是，每种神经退行性疾病也有一个临床前时期，在此期间可能已经发生了潜在的有害炎症事件。随着疾病改变药物的出现，在临床前阶段早期检测来自脑环境的异常信号非常重要，因为诊断症状一旦形成就变得无情，以至于几乎没有治疗对策可供临床医生使用。