Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.,The Lancet

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Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
The Lancet ( IF 168.9 ) Pub Date : 2017-08-01 , DOI: 10.1016/s1470-2045(17)30516-8
Samra Turajlic ₁ , Kevin Litchfield ₂ , Hang Xu ₂ , Rachel Rosenthal ₃ , Nicholas McGranahan ₄ , James L Reading ₅ , Yien Ning S Wong ₅ , Andrew Rowan ₂ , Nnennaya Kanu ₃ , Maise Al Bakir ₂ , Tim Chambers ₂ , Roberto Salgado ₆ , Peter Savas ₇ , Sherene Loi ₇ , Nicolai J Birkbak ₂ , Laurent Sansregret ₂ , Martin Gore ₈ , James Larkin ₈ , Sergio A Quezada ₅ , Charles Swanton ₉

Affiliation

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK; Renal and Skin Units, The Royal Marsden Hospital National Health Service Foundation Trust, London, UK.
Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK.
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Cancer Immunology Unit, Research Department of Haematology, London, UK.
Department of Pathology, Gasthuiszusters, Antwerp, Belgium; Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.
Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.
Renal and Skin Units, The Royal Marsden Hospital National Health Service Foundation Trust, London, UK.
Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK; Department of Medical Oncology, University College London Hospitals, London, UK.

The focus of tumour-specific antigen analyses has been on single nucleotide variants (SNVs), with the contribution of small insertions and deletions (indels) less well characterised. We investigated whether the frameshift nature of indel mutations, which create novel open reading frames and a large quantity of mutagenic peptides highly distinct from self, might contribute to the immunogenic phenotype.

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