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An l-RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis
ChemBioChem ( IF 3.2 ) Pub Date : 2017-08-10 05:00:24 , DOI: 10.1002/cbic.201700362
Adam M. Kabza 1 , Jonathan T. Sczepanski 1
Affiliation  

Mirror images: By employing 5-aminoallyl-UTP during mirror image in vitro selection, a modified l-RNA aptamer was isolated with exceptional affinity towards oncogenic precursor microRNA-19a. These studies demonstrate that expanding the chemical functionality of l-aptamers enables development of robust RNA-binding reagents.

中文翻译:

具有扩展的化学功能的l-RNA适体,可抑制MicroRNA的生物发生。

镜像:通过在体外镜像选择过程中使用5-氨基烯丙基-UTP,分离出对致癌前体microRNA-19a具有非凡亲和力的修饰的1- RNA适体。这些研究表明,扩大1-适配体的化学功能性使得能够开发健壮的RNA结合试剂。
更新日期:2017-08-10
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