Ultrasound (US)‐based biomedicine has been extensively explored for its applications in both diagnostic imaging and disease therapy. The fast development of theranostic nanomedicine significantly promotes the development of US‐based biomedicine. This progress report summarizes and discusses the recent developments of rational design and fabrication of silica‐based micro/nanoparticles for versatile US‐based biomedical applications. The synthetic strategies and surface‐engineering approaches of silica‐based micro/nanoparticles are initially discussed, followed by detailed introduction on their US‐based theranostic applications. They have been extensively explored in contrast‐enhanced US imaging, US‐based multi‐modality imaging, synergistic high‐intensity focused US (HIFU) ablation, sonosensitizer‐enhanced sonodynamic therapy (SDT), as well as US‐triggered chemotherapy. Their biological effects and biosafety have been briefly discussed to guarantee further clinical translation. Based on the high biocompatibility, versatile composition/structure and high performance in US‐based theranostic biomedicine, these silica‐based theranostic agents are expected to pave a new way for achieving efficient US‐based theranostics of disease by taking the specific advantages of material science, nanotechnology and US‐based biomedicine.

中文翻译：

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基于二氧化硅的微/纳米平台用于超声治疗药物生物医学的构建

基于超声（US）的生物医学已经广泛应用于其在诊断成像和疾病治疗中的应用。纳米治疗药物的快速发展极大地促进了基于美国的生物医学的发展。这份进展报告总结并讨论了用于美国通用生物医学应用的基于二氧化硅的微米/纳米颗粒的合理设计和制造的最新进展。首先讨论了基于二氧化硅的微米/纳米颗粒的合成策略和表面工程方法，然后详细介绍了其基于美国的治疗学应用。在造影剂增强型美国成像，基于美国的多模式成像，协同高强度聚焦美国（HIFU）消融，声敏剂增强型声动力学治疗（SDT），以及美国触发的化疗。为了确保进一步的临床翻译，已经简要讨论了它们的生物学效应和生物安全性。基于美国的治疗用生物医学具有高度的生物相容性，多功能的组成/结构和高性能，这些基于二氧化硅的治疗用药物有望通过利用材料科学的特殊优势，为实现高效的美国的疾病治疗学铺平道路，纳米技术和美国的生物医学。