In recent decades, the incidence of many apparently unrelated chronic diseases has markedly increased. Here, I theorize that losses of particular bacterial species of our ancestral microbiota have altered the context in which immunological, metabolic and cognitive development occur in early life, which results in increased disease. This ominous trend suggests that we must refocus efforts to understand and reverse the underlying circumstances that are responsible for our disappearing microbiota.

中文翻译：

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微生物群消失的理论与慢性病的流行

近几十年来，许多看似无关的慢性病的发病率显着增加。在这里，我推论说，祖先微生物群中特定细菌种类的丧失改变了早年发生免疫，代谢和认知发育的环境，从而导致疾病增加。这种不祥的趋势表明，我们必须重新集中精力去理解和逆转造成我们消失的微生物群的潜在环境。