Tumor-associated macrophages (TAMs) contribute to breast cancer progression and dissemination; TAM-targeting strategies aimed at their reprogramming show promising preclinical results. In a new report Guerriero and colleagues demonstrate that a novel HDAC Class IIa inhibitor, TMP195, can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.

中文翻译：

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复极化巨噬细胞可改善乳腺癌治疗。

肿瘤相关巨噬细胞 (TAM) 有助于乳腺癌的进展和传播；针对其重编程的 TAM 靶向策略显示出有希望的临床前结果。在一份新报告中，Guerriero 及其同事证明，一种新型 HDAC IIa 类抑制剂 TMP195 可以将肿瘤中的单核细胞和巨噬细胞重新编程为能够维持强大的 CD8 T 细胞介导的抗肿瘤免疫反应的细胞。