Aptamer-based biosensors may be of significant benefit to forensic analysis by allowing the rapid, sensitive and specific detection of molecular targets relevant to criminal investigation. However, despite the production efficiency, stability and cost effectiveness of aptamer recognition moieties, aptasensors have yet to find commercial employment within any area of forensic science. This review therefore attempts to encourage aptasensor development by initially identifying the methods of selection, sequence analysis and affinity measurement most appropriate for the discovery of suitable aptamers against analytes of forensic interest. A range of optical, electrochemical and mass-sensitive transduction platforms that may be considered amenable to current forensic testing procedures are then discussed. The specific analytical disciplines in which aptasensing technology is likely to be of greatest value, including forensic drug analysis, forensic toxicology and biological evidence and explosives detection are lastly highlighted to stimulate researchers to consider the development of sensors towards these particular target types.

基于适体的生物传感器可以快速，灵敏和特异地检测与犯罪侦查有关的分子靶标，因此对法医分析可能会具有重大意义。然而，尽管适体识别部分具有生产效率，稳定性和成本效益，但是适体传感器尚未在法医学的任何领域中找到商业用途。因此，本综述试图通过初步确定最适合发现针对法医分析物的合适适体的选择，序列分析和亲和力测量方法，来鼓励适体传感器的发展。然后讨论了一系列光学，电化学和质量敏感的转导平台，这些平台可能被认为适合当前的法医测试程序。