Abstract

Oligomerization of substituted indoles and N-methylindoles was investigated in the presence of catalytic amounts of scandium triflate in dichloromethane. Two types of indole oligomer, 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles were obtained based on the substituent on indole ring. This study constitutes the first example of Sc(OTf)₃-catalyzed oligomerization of indoles and gave good yield of 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles.

Oligomerization of substituted indoles and N-methylindoles was investigated in the presence of catalytic amounts of scandium triflate in dichloromethane. Two types of indole oligomer, 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles were obtained based on the substituent on indole ring. This study constitutes the first example of Sc(OTf)₃-catalyzed oligomerization of indoles and gave good yield of 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles.

中文翻译：

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Sc（OTf）3-催化的吲哚低聚反应：一锅合成2- [2,2-双（吲哚-3-基）乙基]苯胺和3-（吲哚-2-基）吲哚

摘要

在二氯甲烷中催化量的三氟甲磺酸scan存在下，研究了取代的吲哚和N-甲基吲哚的低聚。基于吲哚环上的取代基，获得了两种类型的吲哚低聚物，即2- [2，2-双（吲哚-3-基）乙基]苯胺和3-（吲哚-2-基）吲哚。该研究构成了Sc（OTf）₃催化的吲哚低聚的第一个实例，并获得了2- [2,2-双（吲哚-3-基）乙基]苯胺和3-（吲哚-2-基）苯胺的良好收率。吲哚。

在二氯甲烷中催化量的三氟甲磺酸scan存在下，研究了取代的吲哚和N-甲基吲哚的低聚。基于吲哚环上的取代基，获得了两种类型的吲哚低聚物，即2- [2，2-双（吲哚-3-基）乙基]苯胺和3-（吲哚-2-基）吲哚。该研究构成了Sc（OTf）₃催化的吲哚低聚的第一个实例，并获得了2- [2,2-双（吲哚-3-基）乙基]苯胺和3-（吲哚-2-基）苯胺的良好收率。吲哚。