Facilitative carbohydrate transporters—Gluts—have received wide attention over decades due to their essential role in nutrient uptake and links with various metabolic disorders, including diabetes, obesity, and cancer. Endeavors directed towards understanding the mechanisms of Glut-mediated nutrient uptake have resulted in a multidisciplinary research field spanning protein chemistry, chemical biology, organic synthesis, crystallography, and biomolecular modeling. Gluts became attractive targets for cancer research and medicinal chemistry, leading to the development of new approaches to cancer diagnostics and providing avenues for cancer-targeting therapeutics. In this review, the current state of knowledge of the molecular interactions behind Glut-mediated sugar uptake, Glut-targeting probes, therapeutics, and inhibitors are discussed.

中文翻译：

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促进碳水化合物转运的分子工具（胶）

便利性碳水化合物转运蛋白（谷氨酸）由于其在养分吸收中的重要作用以及与各种代谢性疾病（包括糖尿病，肥胖症和癌症）的联系而受到了广泛关注。致力于了解Glut介导的养分吸收机制的努力已导致跨学科的研究领域，涉及蛋白质化学，化学生物学，有机合成，晶体学和生物分子建模。狂犬病成为癌症研究和药物化学的有吸引力的靶标，导致开发出新的癌症诊断方法，并为靶向癌症的治疗方法提供了途径。在这篇综述中，讨论了有关Glut介导的糖摄取，Glut靶向探针，治疗剂和抑制剂背后的分子相互作用的当前知识状态。