Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.

中文翻译：

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ARID1A 突变卵巢癌的关键 HDAC6 依赖性。

AT 丰富的交互域 1A (ARID1A) 中的突变在卵巢癌中很常见。现在的一项研究表明，携带 ARID1A 突变的卵巢癌细胞的存活需要 HDAC6 活性。HDAC6抑制选择性促进ARID1A灭活细胞的凋亡，支持使用HDAC6抑制治疗透明细胞卵巢癌。