Derivatization is the most powerful contribution to the identification and quantification of plant cannabinoids (p-CBDs) by gas chromatography-mass spectrometry (GC-MS): providing volatile derivatives with eminent properties (high selectivity, outstanding sensitivity and mass spectrometric peculiarities). These derivatives are excellent candidates to determine the main p-CBDs, like tetrahydrocannabivarin (THCV), tetrahydrocannabidivarin (CBDV), cannabidiol (CBD), cannabichromene (CBC), cannabicyclol (CBCL), tetrahydrocannabinol (THC), cannabigerol (CBG), cannabinol (CBN), 11-hydroxy-Δ⁹-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THC-COOH). Identification and quantification of p-CBDs is required - partly as trace constituents in complex biological matrices of drug users, partly as main components in seizure samples: in both cases, in extremely different ratios. GC proposals published between 2000 and 2017, along with outstanding pioneer contributions, are reviewed. Procedures, without derivatization and applying various alkylsilyl, acylation and/or esterification techniques were listed, compared and criticized. Further sorting was based on the reagent type, on examined matrices, on enrichment/detection related acquisition protocols and on analytical performance characteristics.

衍生化是通过气相色谱-质谱（GC-MS）鉴定和定量植物大麻素（p-CBD）的最有力贡献：提供具有卓越性能（高选择性，出色的灵敏度和质谱学特性）的挥发性衍生物。这些衍生物是确定主要p-CBD的极佳候选者，如四氢大麻酚（THCV），四氢大麻酚（CBDV），大麻二酚（CBD），大麻二烯（CBC），大麻二环（CBCL），四氢大麻酚（THC），大麻二酚（CBG），大麻酚（CBN），11-羟基Δ ⁹-THC（11-OH-THC）和11-nor-9-羧基-THC（THC-COOH）。对p-CBD的鉴定和定量是必需的-部分是吸毒者复杂生物基质中的痕量成分，部分是癫痫发作样品中的主要成分：在两种情况下，比率都极为不同。审查了2000年至2017年期间发布的GC提案以及杰出的先驱贡献。列出，比较和批评了没有衍生化并且应用各种烷基甲硅烷基的方法，酰化和/或酯化技术。根据试剂类型，所检查的基质，与富集/检测相关的采集规程和分析性能特征进行进一步分选。