In the course of our search for inhibitors of LPS-induced NO production from microbial strains, an ethyl acetate extract of Actinomycete SF2911, isolated from a soil sample collected in Okinawa Prefecture, Japan, showed the inhibitory activity. The active principle was purified and structure determination led to the isolation of one new compound. Since the structure belongs to the terfestatin family, we named it terfestatin D (1). It was found to inhibit cellular migration of breast carcinoma cells as well as NO production. We herein report the isolation, structure elucidation and biological activities of this new compound.

中文翻译：

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来自放线菌菌株SF2911的具有稀有2,6-二脱氧己吡喃糖部分的新型对-三苯苷抑制了癌细胞的迁移。

在我们寻找微生物菌株中LPS诱导的NO产生抑制剂的过程中，从日本冲绳县收集的土壤样品中分离出的放线菌SF2911乙酸乙酯提取物显示出抑制活性。纯化了活性成分，结构确定导致了一种新化合物的分离。由于该结构属于terfestatin家族，因此我们将其命名为terfestatin D（1）。发现抑制乳腺癌细胞的细胞迁移以及NO产生。我们在此报告了该新化合物的分离，结构解析和生物学活性。