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Dendrimer nanohybrid carrier systems: an expanding horizon for targeted drug and gene delivery
Drug Discovery Today ( IF 7.4 ) Pub Date : 2017-07-08 , DOI: 10.1016/j.drudis.2017.06.009
Prashant Kesharwani , Avinash Gothwal , Arun K. Iyer , Keerti Jain , Manish K. Chourasia , Umesh Gupta

Highly controllable dendritic structural design means dendrimers are a leading carrier in drug delivery applications. Dendrimer- and other nanocarrier-based hybrid systems are an emerging platform in the field of drug delivery. This review is a compilation of increasing reports of dendrimer interactions, such as dendrimer–liposome, dendrimer–carbon-nanotube, among others, known as hybrid carriers. This should prompt entirely new research with promising results for these hybrid carriers. It is assumed that such emerging hybrid nanosystems – from combining two already-established drug delivery platforms – could lead the way for the development of newer delivery systems with multiple applicability for latent theranostic applications in the future.



中文翻译:

树状聚合物纳米杂交载体系统:靶向药物和基因递送的广阔视野

高度可控的树枝状结构设计意味着树枝状大分子是药物输送应用中的领先载体。树枝状聚合物和其他基于纳米载体的混合系统是药物输送领域中的新兴平台。本文是有关树枝状大分子相互作用的越来越多的报告的汇编,例如树枝状大分子-脂质体,树枝状大分子-碳纳米管等,被称为杂种载体。这将促进全新的研究,并为这些混合航母带来可喜的结果。可以认为,这种新兴的混合纳米系统将两个已经建立的药物输送平台结合在一起,可以为开发新型的输送系统开辟道路,该系统将来在潜在的治疗学应用中具有多种适用性。

更新日期:2017-07-08
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