The role of medicinal chemistry has changed over the past 10 years. Chemistry had become one step in a process; funneling the output of high-throughput screening (HTS) on to the next stage. The goal to identify the ideal clinical compound remains, but the means to achieve this have changed. Modern medicinal chemistry is responsible for integrating innovation throughout early drug discovery, including new screening paradigms, computational approaches, novel synthetic chemistry, gene-family screening, investigating routes of delivery, and so on. In this Foundation Review, we show how a successful medicinal chemistry team has a broad impact and requires multidisciplinary expertise in these areas.

在过去的十年中，药物化学的作用发生了变化。化学已经成为一个过程中的一步。将高通量筛选（HTS）的输出传递到下一阶段。确定理想临床化合物的目标仍然存在，但是实现这一目标的方法已经改变。现代药物化学负责在整个早期药物发现过程中整合创新，包括新的筛选范例，计算方法，新颖的合成化学，基因家族筛选，研究给药途径等。在本基础回顾中，我们展示了一个成功的药物化学团队如何产生广泛影响，并需要在这些领域具有多学科专业知识。